D2.15 Evaluation of interspecies variation in 3D spheroid formation and API clearance between commercially available primary hepatocytes

D2.12 Mechanistic understanding on the potential for targeted pharmacological responses to mediate chronic effect outcomes from the application of transgenic zebrafish models

D2.10 Evaluation of fish gill uptake and hepatic clearance for 10-20 APIs, including feasibility of the OECD 319b test or organ-chips for prediction of in vivo hepatic clearance of APIs in fish

D2.17 Apply OECD319b to determine the in vitro hepatic clearance of all 25 case study compounds for prediction of their in vivo clearance in fish

D3.12 Intermediate report on Data Management